meta: unsure to what extent this can be changed by Scott, but getting an email for every response to one of his comments (if you've responded to it first) is definitely excessive. There's a 'mute thread' option but I'm unsure if this also mutes responses to my own comments
I'm not looking to sell anything, but I am looking to start a movement of sorts, and I'd love to get advice and support where interests align.
I'm looking to challenge the status quo and lead a rationalist reboot around how we think about, talk about, and treat the condition we currently refer to as diabetes.
When I was diagnosed with type 1 diabetes in 2019, I experienced a remarkably incompetent system of healthcare that initially led me to being depressed.
Thanks in part to an initial misdiagnosis (many adult-onset type 1s are misdiagnosed as type 2), I decided to dig deep into the details of the various physiological conditions, the healthcare dynamics at play, as well as the mental models employed within the diabetes arena, and came away with a completely new outlook.
I've documented my journey, findings, outlook, and suggestions in something I call The Type A Diabetic Manifesto ( http://TypeADiabetic.com ).
In this manifesto, I attempt to use rational thinking as an approach to not just deconstruct existing problems with the current state, but construct new mental models that I hope allow everyone -- ranging from medical practitioners to people with the condition to people who think they don't have the condition but probably do -- to look at insulin disorders and glucose toxicity with a fresh set of eyes.
Unfortunately, some find this way of approaching a sensitive topic quite problematic. For example, the moderators of the diabetes Reddit forums have banned this document, claiming that it peddles in "toxic positivity" and "internalized ableism." The same moderators are on Discord, where they banned me personally from those topics for peddling "dangerous rhetoric." In other forums where it has not been banned, it has been well-received.
Again, any insights, suggestions, or help in getting the word out would be greatly appreciated.
Zikora is my 1-year old daughter, that came down with acute bacteria meningitis with complications of hearing loss and vision loss. The doctors here in Nigeria have recommended cochlear implant which I cannot afford. I am a junior faculty with no insurance and poor salary. Cochlear implant is not performed in Nigeria.
Please if anyone knows of any charity or foundation that can accept to help with supporting Zikora please email me at eennadi@gmail.com or eennadi@plasu.edu.ng.
If you will like to support her cochlear implant, you can use the Gofundme me link or email me for more details.
Reading the comments over the last first months, I see that lots of people working in software read this substack.
This year I am taking a proactive approach to finding software engineering data, which is very hard to find. Previously, I mostly emailed researchers after reading their data oriented paper
The data is out there, we need to find the (few) people who have it, and ask them (my experience is that people don't realise what a gold mine they are sitting on).
When you are talking to those actively involved in software development, don't forget to ask if they have any data that they would be willing to publicly share (I offer a free analysis of software data that can be made public in anonymized form, but am not interested in paid work).
An example of detailed analysis of Agile estimation data
My book Evidence-based Software Engineering discusses what is currently known about software engineering, based on an analysis of all the publicly available data; pdf+code+all data freely available here:
Looking for a co-founder. Don't have an idea, just want to work with someone who is curious and wants to solve a hard problem. I've built 2 unicorns, working with a friend on a third. I'll probably be here for another year or so but for the right idea and person I'd be open to doubling down on something sooner.
Me: Op, strategy and people savvy. Can do Sales too.
The important thing is our personalities complement one another so I expect a few zoom calls getting to know one another before delving into the other pieces.
Lorentz Bio is an early-stage, well-funded cryopreservation company. We're hiring a biologist to help develop and evaluate cryopreservation protocols. This role will start in Boston and may relocate to SF in the next year. We are also hiring for several other positions! https://jobs.lever.co/lorentz.bio/df59acae-afe1-44a5-92e3-a0e9d27495e9
If you are interested in a project that can advance the fight against drug resistance in Africa, using phages please contact me via eennadi@gmail.com
Background
Antimicrobial resistance(AMR) is one of the greatest threats we face as a global community. An essential global public health objective is lowering the burden of infection-related mortality. Previous research has calculated the number of fatalities brought on by drug-resistant infections and sepsis and discovered that infections continue to be the world's leading cause of mortality. The WHO has predicted that by 2030 (https://www.who.int/news/item/29-04-2019-new-report-calls-for-urgent-action-to-avert-antimicrobial-resistance-crisis), antimicrobial resistance could force up to 24 million people into extreme poverty. According to the UK Government-commissioned Review on Antimicrobial Resistance, AMR might result in the yearly death of 10 million people by 2050. It is predicted that 90% of these deaths will occur in Africa and Asia.
According to a recent report published in the Lancet, which estimated deaths and disability-adjusted life-years (DALYs) attributable to and associated with bacterial AMR for 23 pathogens and 88 pathogen–drug combinations in 204 countries and territories in 2019. The study predicted that in 2019, there were an estimated 4·95 million (3·62–6·57) deaths associated with bacterial AMR including 1·27 million (95% UI 0·911–1·71) deaths attributable to bacterial AMR. Six leading pathogens for deaths associated with resistance (Escherichia coli, followed by Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) were responsible for 929 000 (660 000–1 270 000) deaths attributable to AMR and 3·57 million (2·62–4·78) deaths associated with AMR in 2019. The full report can be found here.
A case for sub-Saharan Africa
Based on the report, analysis based on regions of the world, Western sub-Saharan Africa had the highest burden, with 27·3 deaths per 100 000 (20·9–35·3) attributable to AMR and 114·8 deaths per 100 000 (90·4–145·3) associated with AMR, while Australasia had the lowest AMR burden in 2019, with 6·5 deaths per 100 000 (95% UI 4·3–9·4) attributable to AMR and 28·0 deaths per 100 000 (18·8–39·9) associated with AMR in 2019. In Nigeria, communicable diseases accounted for 66% of morbidity in 2015 There is an urgent need to address this problem in Sub-Saharan Africa.
Phages as an alternative to antibiotics
Phages have been proposed as an alternative to drug resistance. While phages have been used successfully in Europe, Australia and the USA. No report on phage therapy use in Africa. Phage research is neglected in Africa. A recent survey of phage scientists under the Africa phage forum showed that funding, lack of skill sets and infrastructure are the major setbacks preventing success in phage research in Africa.
To stimulate phage research as an alternative to antibiotics in Africa, I propose coordinated and strategic support. This support should focus on:
1 Influencing policy that will allow for the adoption and use of phage therapy in Africa. No country within Africa has a framework for the adoption of phage therapy
2 Address the infrastructure problem. This can be done by setting up phage banks in regions of Africa. In Nigeria, I am currently building a phage bank that can isolate, characterize and purify phages for use as phage therapy against the WHO priority pathogens. We can encourage this kind of phage banks across Africa. Funding has been a major challenge even for the phage bank in Nigeria.
3 Training, Phages for global health have supported the training of phage researchers in Africa. They can be encouraged to do more
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meta: unsure to what extent this can be changed by Scott, but getting an email for every response to one of his comments (if you've responded to it first) is definitely excessive. There's a 'mute thread' option but I'm unsure if this also mutes responses to my own comments
I'm not looking to sell anything, but I am looking to start a movement of sorts, and I'd love to get advice and support where interests align.
I'm looking to challenge the status quo and lead a rationalist reboot around how we think about, talk about, and treat the condition we currently refer to as diabetes.
When I was diagnosed with type 1 diabetes in 2019, I experienced a remarkably incompetent system of healthcare that initially led me to being depressed.
Thanks in part to an initial misdiagnosis (many adult-onset type 1s are misdiagnosed as type 2), I decided to dig deep into the details of the various physiological conditions, the healthcare dynamics at play, as well as the mental models employed within the diabetes arena, and came away with a completely new outlook.
I've documented my journey, findings, outlook, and suggestions in something I call The Type A Diabetic Manifesto ( http://TypeADiabetic.com ).
In this manifesto, I attempt to use rational thinking as an approach to not just deconstruct existing problems with the current state, but construct new mental models that I hope allow everyone -- ranging from medical practitioners to people with the condition to people who think they don't have the condition but probably do -- to look at insulin disorders and glucose toxicity with a fresh set of eyes.
Unfortunately, some find this way of approaching a sensitive topic quite problematic. For example, the moderators of the diabetes Reddit forums have banned this document, claiming that it peddles in "toxic positivity" and "internalized ableism." The same moderators are on Discord, where they banned me personally from those topics for peddling "dangerous rhetoric." In other forums where it has not been banned, it has been well-received.
Again, any insights, suggestions, or help in getting the word out would be greatly appreciated.
https://www.gofundme.com/f/help-zikora-recover-from-meningitis-complication?utm_campaign=p_cp+share-sheet&utm_medium=copy_link_all&utm_source=customer
Zikora is my 1-year old daughter, that came down with acute bacteria meningitis with complications of hearing loss and vision loss. The doctors here in Nigeria have recommended cochlear implant which I cannot afford. I am a junior faculty with no insurance and poor salary. Cochlear implant is not performed in Nigeria.
Please if anyone knows of any charity or foundation that can accept to help with supporting Zikora please email me at eennadi@gmail.com or eennadi@plasu.edu.ng.
If you will like to support her cochlear implant, you can use the Gofundme me link or email me for more details.
The proposed removal of Human Rights in the UK for the Greater Good
And how it could apply to unvaccinated citizens
https://nakedemperor.substack.com/p/the-proposed-removal-of-human-rights
Why is the narrative changing? And in lockstep
Whilst case numbers are rising
https://nakedemperor.substack.com/p/why-is-the-narrative-changing-and
Reading the comments over the last first months, I see that lots of people working in software read this substack.
This year I am taking a proactive approach to finding software engineering data, which is very hard to find. Previously, I mostly emailed researchers after reading their data oriented paper
https://shape-of-code.com/2017/02/02/i-have-been-reading-your-interesting-paper/
Now I'm promoting the crowdsourcing the search for people who look as if they might have interesting data, e.g., company CTOs, and Agile coaches
https://shape-of-code.com/2022/01/09/join-a-crowdsourced-search-for-software-engineering-data/
The data is out there, we need to find the (few) people who have it, and ask them (my experience is that people don't realise what a gold mine they are sitting on).
When you are talking to those actively involved in software development, don't forget to ask if they have any data that they would be willing to publicly share (I offer a free analysis of software data that can be made public in anonymized form, but am not interested in paid work).
An example of detailed analysis of Agile estimation data
https://arxiv.org/abs/1901.01621
My book Evidence-based Software Engineering discusses what is currently known about software engineering, based on an analysis of all the publicly available data; pdf+code+all data freely available here:
http://knosof.co.uk/ESEUR/
Looking for a co-founder. Don't have an idea, just want to work with someone who is curious and wants to solve a hard problem. I've built 2 unicorns, working with a friend on a third. I'll probably be here for another year or so but for the right idea and person I'd be open to doubling down on something sooner.
Me: Op, strategy and people savvy. Can do Sales too.
You: ideally technical/analytical, product-oriented.
The important thing is our personalities complement one another so I expect a few zoom calls getting to know one another before delving into the other pieces.
Glad the terminally online have found a place to date/eventually murder each other
Lorentz Bio is an early-stage, well-funded cryopreservation company. We're hiring a biologist to help develop and evaluate cryopreservation protocols. This role will start in Boston and may relocate to SF in the next year. We are also hiring for several other positions! https://jobs.lever.co/lorentz.bio/df59acae-afe1-44a5-92e3-a0e9d27495e9
If you are interested in a project that can advance the fight against drug resistance in Africa, using phages please contact me via eennadi@gmail.com
Background
Antimicrobial resistance(AMR) is one of the greatest threats we face as a global community. An essential global public health objective is lowering the burden of infection-related mortality. Previous research has calculated the number of fatalities brought on by drug-resistant infections and sepsis and discovered that infections continue to be the world's leading cause of mortality. The WHO has predicted that by 2030 (https://www.who.int/news/item/29-04-2019-new-report-calls-for-urgent-action-to-avert-antimicrobial-resistance-crisis), antimicrobial resistance could force up to 24 million people into extreme poverty. According to the UK Government-commissioned Review on Antimicrobial Resistance, AMR might result in the yearly death of 10 million people by 2050. It is predicted that 90% of these deaths will occur in Africa and Asia.
According to a recent report published in the Lancet, which estimated deaths and disability-adjusted life-years (DALYs) attributable to and associated with bacterial AMR for 23 pathogens and 88 pathogen–drug combinations in 204 countries and territories in 2019. The study predicted that in 2019, there were an estimated 4·95 million (3·62–6·57) deaths associated with bacterial AMR including 1·27 million (95% UI 0·911–1·71) deaths attributable to bacterial AMR. Six leading pathogens for deaths associated with resistance (Escherichia coli, followed by Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) were responsible for 929 000 (660 000–1 270 000) deaths attributable to AMR and 3·57 million (2·62–4·78) deaths associated with AMR in 2019. The full report can be found here.
A case for sub-Saharan Africa
Based on the report, analysis based on regions of the world, Western sub-Saharan Africa had the highest burden, with 27·3 deaths per 100 000 (20·9–35·3) attributable to AMR and 114·8 deaths per 100 000 (90·4–145·3) associated with AMR, while Australasia had the lowest AMR burden in 2019, with 6·5 deaths per 100 000 (95% UI 4·3–9·4) attributable to AMR and 28·0 deaths per 100 000 (18·8–39·9) associated with AMR in 2019. In Nigeria, communicable diseases accounted for 66% of morbidity in 2015 There is an urgent need to address this problem in Sub-Saharan Africa.
Phages as an alternative to antibiotics
Phages have been proposed as an alternative to drug resistance. While phages have been used successfully in Europe, Australia and the USA. No report on phage therapy use in Africa. Phage research is neglected in Africa. A recent survey of phage scientists under the Africa phage forum showed that funding, lack of skill sets and infrastructure are the major setbacks preventing success in phage research in Africa.
To stimulate phage research as an alternative to antibiotics in Africa, I propose coordinated and strategic support. This support should focus on:
1 Influencing policy that will allow for the adoption and use of phage therapy in Africa. No country within Africa has a framework for the adoption of phage therapy
2 Address the infrastructure problem. This can be done by setting up phage banks in regions of Africa. In Nigeria, I am currently building a phage bank that can isolate, characterize and purify phages for use as phage therapy against the WHO priority pathogens. We can encourage this kind of phage banks across Africa. Funding has been a major challenge even for the phage bank in Nigeria.
3 Training, Phages for global health have supported the training of phage researchers in Africa. They can be encouraged to do more